Health Conditions A-Z Infectious Diseases Lyme Disease Signs and Symptoms of Lyme Disease A skin rash and flu-like symptoms are the first signs of Lyme disease. If left untreated, symptoms like a stiff neck and drooping face can develop. By Laura Dorwart Laura Dorwart Laura Dorwart is a health journalist with expertise in disability rights, mental health, and pregnancy-related conditions. She has written for publications like SELF, The New York Times, VICE, and The Guardian. health's editorial guidelines Published on March 7, 2023 Medically reviewed by Anita C. Chandrasekaran, MD Medically reviewed by Anita C. Chandrasekaran, MD Anita C. Chandrasekaran, MD, MPH, is a rheumatologist at Hartford Healthcare Medical Group in Connecticut. She is board-certified in both rheumatology and internal medicine. learn more Share Tweet Pin Email In This Article View All In This Article Early Symptoms Later Symptoms When to See a Healthcare Provider Ladislav KubeÅ¡ / Getty Images Lyme disease is an infection you can develop after a blacklegged tick carrying the Borrelia burgdorferi bacterium bites you. Within days or weeks of the bite, you can experience symptoms like a rash, fever, chills, and other flu-like symptoms. When left untreated, Lyme disease can lead to facial paralysis, arthritis, irregular heartbeat, and nerve pain. Early Symptoms The early signs of Lyme disease can start to develop from three to 30 days after an infected tick bites you. If you have been bitten, look out for these symptoms. Erythema Migrans About 70-80% of people with Lyme disease develop an erythema migrans rash, usually about a week after the bite. An erythema migrans rash often resembles a bull’s eye—a small circle with a larger ring around it—but it may also appear as a discolored area of the skin. This discolored area can be darker or lighter than your natural skin tone. The rash usually begins in the bitten area of the skin and expands over the following days. It can reach up to 12 inches in diameter. Erythema migrans rashes aren’t usually painful, swollen, or itchy, but they might feel warm. Flu-Like Symptoms Many people with Lyme disease also experience flu-like symptoms shortly after infection. These early symptoms, which can appear with or without an erythema migrans rash, may include: Fever Chills Fatigue Muscle pain Joint pain Swollen lymph nodes Headache Later Symptoms Lyme disease can usually be effectively treated with antibiotics. If left untreated, the infection can spread to other parts of your body, such as your nervous system, joints, and cardiovascular system. Symptoms of untreated Lyme disease include: Dizziness Shortness of breath New erythema migrans rashes Fatigue Body aches Brain fog Long-Term Complications Untreated Lyme disease can sometimes lead to severe or chronic health complications. Neurologic Lyme Disease If the infection spreads to your peripheral or central nervous systems, you may experience complications of neurologic Lyme disease. Neurologic Lyme disease can cause meningitis, an inflammation of the brain and spinal cord. Meningitis can lead to symptoms like: FeverStiff neckSevere headacheVision problemsLight sensitivity Neurologic Lyme disease can also cause facial palsy, which is when the facial muscles become paralyzed, causing drooping on one or both sides of the face. An inflammation of the nerves, or radiculoneuritis, is another complication of neurologic Lyme disease. This can lead to numbness, pain, or weakness in the arms or legs. Lyme Arthritis If the infection spreads to your joint tissues, it can cause Lyme arthritis, or inflammation in one or more joints. The affected joints will typically show obvious swelling, such as one knee appearing larger than the other. The joint may also feel warm and painful to move. Lyme arthritis can develop about one to three months after the initial infection. Lyme Carditis If the infection spreads to your heart, it can lead to Lyme carditis, which causes an interruption in the electrical signals involved in controlling the heartbeat. Symptoms include: LightheadednessDifficulty breathingHeart palpitationsChest painFainting About 1% of people with Lyme disease develop this heart condition, usually about one to two months after they were bitten. When to See a Healthcare Provider Talk to a healthcare provider if you see the formation of what you think may be an erythema migrans rash or start feeling sick a few days or weeks after you suspect you may have been or know you were bitten by a tick. Your healthcare provider can make a diagnosis of Lyme disease based on the results of a blood test, your potential for exposure to blacklegged ticks, and an assessment of your symptoms. If you test negative at first, your healthcare provider may recommend that you take another test in a few weeks. Most infections clear up with antibiotics over the course of two to four weeks. A Quick Review Lyme disease is a bacterial infection that you can contract after a bite from an infected blacklegged tick. Within a few days to a month of being bitten, most people with Lyme disease develop an erythema migrans rash that expands from the area around the bite. Other early symptoms of Lyme disease include muscle pain, fever, chills, and headache, which may appear even if you don’t develop a rash. When left untreated, Lyme disease can lead to complications like arthritis, carditis (a heart condition), meningitis, nerve pain, and facial palsy. Some people also experience symptoms like cognitive issues, additional rashes, fatigue, and dizziness. See a healthcare provider if you feel sick after being bitten by a tick. Was this page helpful? Thanks for your feedback! Tell us why! Other Submit Sources Health.com uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Centers for Disease Control and Prevention. Lyme disease. Centers for Disease Control and Prevention. Signs and symptoms of untreated Lyme disease. MedlinePlus. Lyme disease. Centers for Disease Control and Prevention. Neurologic Lyme disease. Arvikar SL, Steere AC. Diagnosis and treatment of Lyme arthritis. Infect Dis Clin North Am. 2015;29(2):269-80. doi:10.1016/j.idc.2015.02.004 Centers for Disease Control and Prevention. Lyme arthritis. Centers for Disease Control and Prevention. Lyme carditis. Radesich C, Del Mestre E, Medo K, et al. Lyme carditis: from pathophysiology to clinical management. Pathogens. 2022;11(5):582. doi:10.3390/pathogens11050582 Centers for Disease Control and Prevention. Lyme disease frequently asked questions (FAQs).