What Does a Lyme Disease Rash Really Look Like? These Pictures Explain It

A telling sign of Lyme disease is a red, circular or oval rash that expands over time like a bulls-eye. Doctors call it "erythema migrans." But if you're looking for a bulls-eye pattern and ignoring other types of skin rashes and lesions, you're probably missing an important clue to the diagnosis. Surprise, surprise: Relatively few Lyme rashes mimic the concentric circles of a dart board.

The classic target pattern represents just 20% of Lyme-related skin lesions in North America, noted John Aucott, MD, associate professor of medicine at Johns Hopkins University School of Medicine in Baltimore and director of the Johns Hopkins Lyme Disease Research Center.

"Eighty percent don't look like that, and they constantly get misdiagnosed as spider or bug bites," Dr. Aucott told Health.

The fact is that Lyme disease rash can present itself in different ways, per the Centers for Disease Control and Prevention (CDC). How it appears on your body may depend, in part, on how long you've had it and where it shows up on your body.

Generally, erythema migrans is circular, because it spreads centrifugally (away from the center) from the point of the tick bite, said Dr. Aucott. But it can be more oval or elongated in shape if, for instance, the tick took its blood meal in the groove of your groin.

Its appearance may also depend on your skin tone, Andrea Swei, PhD, an associate professor specializing in tick-borne diseases at San Francisco State University, told Health. In fact, some research, like a 2019 article published in Biomedical Journal of Scientific & Technical Research, suggests that Lyme rashes may not always be obvious in darker-skinned individuals, which can lead to disparities in diagnosis and treatment.

Healthcare providers also point out that it's possible to have Lyme disease with no visible rash, or a rash that clears up on its own before you notice it.

What Do the Rashes of Lyme Disease Look Like?

Uniformly Red Rash

This is the most common Lyme disease rash. It can be circular or oval and appear anywhere on the body. The redness is evidence of inflammation, explained Dr. Aucott. And just because it doesn't have a target appearance doesn't mean it's not Lyme disease. If you develop a solid rash during tick season in a Lyme-endemic area, chances are it's not a spider bite, said Dr. Aucott.

Classic Bulls-Eye Pattern Rash

This is the image you often see in articles and stories on Lyme disease: a concentric circle pattern consisting of a red bulls-eye dead center and a ring of "central clearing" bordered by an outer red ring.

"Sometimes it goes from red to white to red; sometimes it's white to red, but any time you have central clearing, it gives that target appearance," explained Dr. Aucott. Although it's pretty indicative of Lyme, it's not the most common Lyme rash; nor is it a foolproof sign of the disease, added Dr. Aucott. Another tick-borne disease, called southern tick-associated rash illness, can cause a circular lesion too.

Multiple Red Rashes

Early Lyme disease that spreads, or "disseminates," through the bloodstream can cause multiple red lesions, Jennie Johnson, MD, infectious diseases specialist, associate medical director at Infectious Disease and Immunology Center at The Miriam Hospital, and co-director at Lifespan Lyme Disease Center in Providence, Rhode Island, told Health. When this happens, it means bacteria are no longer isolated to the area of the skin where the tick bite occurred. The CDC describes these rashes as having "dusky centers."

Red-Blue or Bluish Lesions

These rashes may or may not have central clearing, according to the CDC. If there's clearing, that portion of the person's skin will take on a bluish tinge, observed Dr. Johnson. The trouble with these rashes is they can be mistaken for bruises due to their reddish-blue color, said Dr. Aucott.

Central Blistering Rash

A vesicular rash, one that blisters in the center, is uncommon. These lesions account for just 2% of Lyme rashes, according to Dr. Aucott, but he says they're really important. That's because people don't realize Lyme can cause rashes with central blistering—or even central crusting after the blisters have popped. Occasionally, a crusty black scab, called an eschar, will develop, noted Dr. Aucott, "and those [almost] always get misdiagnosed."

Can Lyme Disease Rash Itch?

If you develop a Lyme disease rash, you probably won't be scratching your skin until it's raw. Still, Lyme disease rashes can be slightly itchy, even mildly painful, said Dr. Aucott, but they don't itch like a case of poison ivy.

Lyme rashes often feel warm to the touch as well. Your healthcare provider may perform what's called a "crossover test" to gauge whether the area feels warmer than the rest of your skin, said Dr. Johnson. Here's what that involves: Let's say the rash is behind one knee. You place one hand on the rash and your other hand in the same area of the unaffected knee, wait a few seconds, and then switch hands. If there's a difference in temperature, you'll notice it.