What You Need to Know About Shoulder Injury Related to Vaccines SIRVA

It's a very rare side effect associated with a shot being administered incorrectly.

If you've received a vaccine, you may have experienced common side effects, like a sore arm or low-grade fever. However, you may not be aware of a potential, rare side effect called shoulder injury related to vaccine administration (SIRVA). While SIRVA can cause discomfort, the life-saving benefits of vaccines still outweigh the risks of developing this rare side effect. Learning about SIRVA can help you to prevent it or if you think you have it, address symptoms with a healthcare provider.

What Is SIRVA?

Ken Donohue, MD, a Yale Medicine orthopedic surgeon and shoulder specialist, explained to Health that SIRVA is a rare condition in which pain and loss of function in the shoulder occurs following a vaccination.

Just how uncommon is it? "I have seen very few cases of this in my patients as an orthopedic shoulder specialist," Dr. Donohue maintained. And because it is so rare, little information is available about it. Some medical professionals even deny its existence.

For example, in a 2022 review of the literature published in the journal Clinical Orthopaedics and Related Research, study authors noted that the National Academy of Medicine's Committee on the Adverse Effects of Vaccines' position on SIRVA is that there is no question that the evidence confirms that injectable vaccines can cause deltoid (shoulder muscle) bursitis.

But these study authors also note that the American Academy of Orthopaedic Surgeons (AAOS) has published two positions on this topic, first in 2017 and again in 2020, stating that there is no evidence that vaccines cause any injuries to the shoulder.

Other reviews seem to favor the National Academy of Medicine's position. For example, a 2022 review of the literature published in the journal Clinical Orthopaedics and Related Research stated that based on the studies they reviewed, though "exceedingly rare," about one out of 130,000 vaccinations results in SIRVA.

Another 2022 literature review published in the journal Vaccine stated that "SIRVA is an increasingly recognized complication after vaccination" and suggested that risk factors for SIRVA include female sex, a thin physical build, a smaller deltoid muscle, and improper injection techniques.


Dr. Donohue explained that while doctors and nurses are properly trained in using the correct needle length and landmarking—determining where a vaccine should be given in the arm—sometimes the injection is not placed where it should be.

"When a needle is injected too deep, the deltoid muscle can be penetrated, and structures within the shoulder can be damaged, such as the rotator cuff or joint capsule," Dr. Donohue explained. In very rare cases, the axillary or radial nerves in the upper arm could be injured.

A 2018 study published in the Canadian Pharmacists Journal specified that SIRVA "occurs when an injection is administered too high in the arm, and the vaccine is delivered to the shoulder capsule instead of the deltoid muscle."

These study authors also stated that injecting into the wrong part of the arm initiates an inflammatory response, which damages structures in the shoulder—like tendons and bursa.

Symptoms and Treatment

While dull muscle ache pain after a vaccine injection is common, it usually disappears on its own within days. With SIRVA, an individual will usually start feeling pain within 48 hours of the vaccination, and the pain doesn't improve over time.

For people who experience SIRVA, months may pass by, and they will say they have increasing pain, weakness, and impaired mobility in the injected arm. "Simple actions like lifting your arm to brush your teeth can cause pain," said Kelly Grindrod, PharmD, a professor at the School of Pharmacy at Waterloo and one of the authors of the 2018 study.

According to the 2022 review in Clinical Orthopaedics and Related Research, the most common symptoms of SIRVA are shoulder pain and reduced range of motion, and the most common initial diagnoses tend to be shoulder bursitis, adhesive capsulitis (known as frozen shoulder), and rotator cuff tears.

These conditions may occur, per a 2022 Journal of Hand Surgery Global Online review, when injections are incorrectly placed in certain locations in the shoulder (e.g., an injection in or near the auxiliary nerve may result in nerve irritation, numbness, tingling, or weakness).

People experiencing these symptoms should try to talk to a healthcare provider. "It's important that we learn to recognize these signs of SIRVA so that we can access appropriate treatment," Grindrod added.

To diagnose SIRVA, an ultrasound scan or MRI is needed, which can also determine the level and type of damage, per a 2022 study in the Canadian Medical Association Journal. Common treatments for SIRVA include lifestyle and work modifications, non-steroidal anti-inflammatory drugs (NSAIDs), and physical therapy.

If these conservative treatments don't work, corticosteroid injections may help, and surgery may be recommended in more severe cases.

Prevention of SIRVA

Most importantly, healthcare providers who administer vaccinations need to use proper vaccination landmarking techniques, according to Grindrod. However, if you are the one getting vaccinated, there are a few precautions you can take.

"It's important to let the people administrating vaccinations see the entire shoulder so that they can reference the necessary landmarks for proper injection," Dr. Donohue said.

"Wear a sleeveless shirt or shirt that can be removed in order to reveal the entire shoulder. Rolling up the sleeve may prevent the person administering the vaccine from seeing all of the landmarks necessary to administer appropriately."


While prevention of SIRVA partly depends on the person administering the injection, you can help by making sure your arm is fully visible for them to properly landmark for the injection. It's also important to keep in mind that vaccines save lives and that the risk of SIRVA is very small.

"I can't emphasize enough that the risks associated with not being vaccinated far outweigh the possibility of SIRVA," Dr. Donohue said. "My advice is to still be vaccinated as you normally would but to talk to your primary care doctor about any concerns you may have."

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6 Sources
Health.com uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. MacMahon A, Nayar SK, Srikumaran U. What do we know about shoulder injury related to vaccine administration? An updated systematic review. Clinical Orthopaedics and Related Research®. 2022;480(7):1241–1250.

  2. MacMahon A, Nayar SK, Srikumaran U. What do we know about shoulder injury related to vaccine administration? An updated systematic review. Clin Orthop Relat Res. 2022;480(7):1241-1250.

  3. Yuen WLP, Loh SYJ, Wang DB. SIRVA (Shoulder injury related to vaccine administration) following mRNA COVID-19 Vaccination: Case discussion and literature review. Vaccine. 2022;40(18):2546-2550.

  4. Bancsi A, Houle SKD, Grindrod KA. Getting it in the right spot: Shoulder injury related to vaccine administration (Sirva) and other injection site events. Can Pharm J. 2018;151(5):295-299.

  5. Shoulder injury related to vaccine administration: diagnosis and management. Journal of Hand Surgery Global Online. 2022;4(2):111-117.

  6. Chow JCK, Koles SL, Bois AJ. Shoulder injury related to SARS-CoV-2 vaccine administration. CMAJ. 2022;194(2):E46-E49.

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