Health Conditions A-Z Eye Disorders Dry Eye 7 Medications That Can Cause Dry Eyes A surprising number of over-the-counter and prescription meds can cause dry eyes. By Karen Pallarito Karen Pallarito Twitter Karen is a senior editor at Health, where she produces health condition “explainers” backed by current science. health's editorial guidelines Updated on October 10, 2022 Medically reviewed by Dagny Zhu, MD Medically reviewed by Dagny Zhu, MD Dagny Zhu, MD, is the owner and medical director of Hyperspeed LASIK (an NVISION company). learn more Share Tweet Pin Email Getty Images Inadequate tear production in your eyes can make them feel dry or gritty, burn, or sting, among other symptoms. Dry eye syndrome is a chronic condition that's more serious than just a one-time bout of dry eyes. There are different causes, and it can be a medication side effect. If your eyes are dry and irritated, ask yourself: Could the medicines you pop each day be the culprit? People taking over-the-counter and prescription medications may not realize the extent to which common pills, sprays, drops, and liquids can starve the eyes of adequate hydration. Dry eyes can be caused by cold relief medicines, prescription heart medicines, allergy treatments, and more. And for people on multiple drugs, the potential risk to the eyes is compounded, said Stephanie Crist, Pharm.D., assistant professor of pharmacy practice at St. Louis College of Pharmacy in Missouri. If you are taking any medications that are drying out your eyes, talk to your healthcare provider to see how you can find relief for your eyes. Antihistamines and Dry Eyes Antihistamines such as Flonase (fluticasone), Allegra (fexofenadine), Claritin (loratadine), Zyrtec (Cetirizine), and Benadryl (diphenhydramine) block the effect of the chemical histamine, which the body produces in its attack against allergens. Antihistamines can provide much-needed relief from allergy and cold symptoms, including sneezing, itching, watery eyes, and a runny nose. However, they can also do a number on your eyes, like reducing the watery tear film that keeps them moist. The fact that dry eyes have symptoms similar to an allergy can be confusing. "If you have a scratchy, gravelly graininess that's lack of watery tear, [t]hen ask yourself, did I just take a Benadryl the other day or an allergy medication because I started sneezing? That can dry you out," explained Steven Maskin, MD., medical director of the Dry Eye and Cornea Treatment Center in Tampa, Florida. Nasal Decongestants What's soothing to a stuffy nose may not be so gentle on the eyes. Over-the-counter decongestants are the go-to medicines for easing cold and flu symptoms, hay fever, and sinusitis. They work by narrowing blood vessels in the membranes of the nose, which reduces blood flow to swollen nasal tissue. This allows blocked-up noses to breathe with greater ease. Nasal decongestants come as pills, liquids, and nasal sprays. They're sold under several brand names containing ingredients like phenylephrine, pseudoephedrine, and oxymetazoline. However, like antihistamines, decongestants decrease tear production. Some products on the drugstore shelves combine an antihistamine and a decongestant—a double whammy on the eyes. Blood Pressure Lowering Drugs People who take prescription medications to lower their blood pressure and treat certain heart conditions can also experience dry eyes. Beta-blockers, for example, slow heart rate, reduce the force of heart muscle contractions, and lessen blood vessel contraction. But these drugs are thought to decrease sensitivity of the cornea, the transparent window of the eye. "When that happens, it can dampen the stimulus for tear glands to release tears," Dr. Maskin explained. Diuretics, also known as water pills, are another type of blood pressure-lowering medicine that works by encouraging the body to excrete more urine. Drugs like Microzide (hydrochlorothiazide) and Lasix (furosemide) flush excess water out of the body—and the eyes. Antidepressant, Antipsychotic, and Parkinson's Medications Elavil (amitriptyline), a tricyclic antidepressant, and thioridazine, which is prescribed for treating schizophrenia, are among a group of medicines that have anticholinergic effects. These drugs prevent the transmission of certain nerve impulses and have certain adverse effects, like dry eyes. Artane (trihexyphenidyl), used to combat stiffness, tremors, and spasms in Parkinson's disease, has the same anticholinergic properties. "Normally, a healthy nerve would sense eye dryness and send a signal that gets passed along until it reaches its destination and tears are released, but when that communication network breaks down, the message becomes undeliverable, and that leads to dry eye," Dr. Maskin explained. Popular medicines like Zoloft (sertraline) and Paxil (paroxetine) belong to a different class of antidepressants called selective serotonin reuptake inhibitors (SSRIs), but they can also cause dry eyes. Hormone Therapy and Oral Contraceptives Hormone therapy has a complicated effect on dry eyes. People who take hormone therapy to treat the effects of menopause, particularly estrogen alone, have a greater likelihood of developing dry eyes. Post-menopausal people who used estrogen-only replacement therapy had a 70% increased risk of dry eye disease, and those who used a combination of estrogen and progesterone had a 30% increased risk of dry eyes. You are also more likely to develop dry eyes due to hormonal changes linked to the use of birth control pills. People who use birth control pills had a higher SANDE score, which is a scoring system of dry eye symptoms: a high score corresponds to dry eyes. "The exact relationship between hormones and eye dryness is unclear," explained Dr. Maskin. "It could be that estrogen adversely affects the oil-producing glands of the eye. Estrogen may also reduce the so-called aqueous—or water layer—of the tear film," Dr. Maskin added. Acne Medicine and Dry Eyes Dermatologists sometimes prescribe isotretinoin for severe, scarring acne or acne that doesn't respond to other treatments. Once sold under the brand Accutane, this powerful drug has a drying effect on oil glands. It's known to cause irritation of the eyes and eyelids, among other common side effects. "It decreases overall mucus production and secretion," said Dr. Crist. Accutane's checkered history includes a link to birth defects, depression, suicidal thoughts, and bowel disorders. Although drugmaker Roche Pharmaceuticals pulled it from the market in 2009, generic versions are still available. Eyedrops It may sound surprising, but certain eyedrops actually exacerbate dry eye symptoms. "Avoid the drops that 'get the red out,'" Dr. Maskin cautioned. Visine (tetrahydrozoline ophthalmic), for one, works by narrowing blood vessels in the eyes to reduce redness. But when the drops wear off, the vessels dilate and can become inflamed again. "The key is to find out what's causing the redness, not to try to hide the redness," Dr. Maskin said. A Quick Review You are likely to grab an over-the-counter relief product to help deal with your cold, flu, or allergy symptoms, not realizing one irritating and common side effect: dry eyes. Our eyes need to remain lubricated to function effectively. However, the use of some medications to treat symptoms, and certain conditions, can dry out your eyes. If you use antihistamines, nasal decongestants, blood pressure lowering drugs, antidepressants, antipsychotic, and Parkinson's medications, hormone therapy, oral contraceptives, acne medicine, and eyedrops and experience chronic dry, irritated eyes—visit a medical professional to diagnose and treat your symptoms. Was this page helpful? Thanks for your feedback! Tell us why! Other Submit Sources Health.com uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Akpek EK, Amescua G, Farid M, et al. Dry eye syndrome preferred practice pattern. Ophthalmology. 2019;126(1):P286-P334. DOI. 10.1016/j.ophtha.2018.10.023 Alburayk KB, Alqahtani BS, Alsarhani WK. 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