Cancer patients may be able to fight chemotherapy-induced nausea using a common pantry spice—ginger. In the largest study of its kind to date, researchers found that a smidgen of purified ginger given in supplement form—equivalent to one-quarter teaspoon to one-half a teaspoon of the spice each day—could reduce chemotherapy-related nausea by 40% when used in combination with traditional anti-nausea medications.

Health.com
May 14, 2009


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By Jacquelyne Froeber
THURSDAY, May 14, 2009 (Health.com) — Cancer patients may be able to fight chemotherapy-induced nausea using a common pantry spice—ginger.

In the largest study of its kind to date, researchers found that a smidgen of purified ginger given in supplement form—equivalent to one-quarter teaspoon to one-half teaspoon of the spice each day—could reduce chemotherapy-related nausea by 40% on the first day of treatment when used in combination with traditional anti-nausea medications.

The findings were released Thursday and will be presented later this month at the American Society of Clinical Oncology annual meeting.

"If we can reduce nausea on day one, then patients tend to have reduced nausea throughout treatment," says lead study author Julie L. Ryan, PhD, of the University of Rochester Medical Center in Rochester, N.Y. About 70% of cancer patients experience nausea during chemotherapy, although anti-emetic drugs often help prevent actual vomiting.

In the new study, 644 people—mostly breast-cancer patients—were given supplements twice a day for six days, including the three days before and after they started chemotherapy. The patients took 0.5, 1, or 1.5 grams of ginger daily, which was divided into two doses, or they took identical placebo supplements that contained no ginger. Ginger-taking patients—regardless of daily dose—reported a greater reduction in nausea on the first day of treatment than those taking a placebo.

Those taking the two lowest doses of ginger reported greater relief than those taking the highest dose, however, so taking more of the spice isn't necessarily better.

"We were surprised to find that the lowest doses were the most effective. I am guessing that at one gram the gut reaches maximum absorption," Ryan says.

Next page: What about ginger ale or ginger snaps?

The reduction in nausea was substantial, she says. The patients taking a placebo reported about a four or five on a seven-point nausea scale, meaning they were extremely nauseated. In comparison, ginger-taking patients tended to report one or two, which is little to no nausea. The supplements reduced vomiting by roughly 5% in the study, says Ryan, but very few of the patients had any vomiting due to the anti-emetic drugs they were taking.

"It's an interesting and rigorous study in the field of complementary medicine, and an important step forward in improving quality of care for the 70% of patients who undergo chemotherapy and experience nausea and vomiting," says Douglas Blayney, MD, president-elect at the American Society of Clinical Oncology.

Prior research had suggested that ginger supplements couldn't reduce nausea during chemotherapy, but Ryan says timing is everything: By giving the supplement three days prior to treatment—which had not been done in previous studies—the anti-inflammatory property of ginger had a head start on quashing queasiness.

Studies have suggested that ginger can also quell nausea caused by pregnancy, motion sickness, and anesthesia.

Ted Gansler, MD, director of medical content for the American Cancer Society, says complementary therapies such as ginger may work for some patients, but "most oncologists would not recommend counting on them as alternatives—especially for those receiving chemotherapy drugs known to cause the most severe nausea and vomiting."

If you're feeling queasy, Ryan says, consuming fresh ginger root from the grocery store can help, but purified capsules may work better due to their easier absorption in the gastrointestinal tract. In theory, ginger-containing products such as ginger ale, ginger snaps, and other products could reduce nausea, too, but only if they contained real ginger root, not just ginger flavoring.

Ginger has few side effects, but it could interfere with blood clotting and cause excessive bleeding, says Dr. Gansler. Consult your doctor before taking any supplement.

When dealing with chemotherapy-induced nausea—or any upset stomach—the American Cancer Society recommends eating dry foods such as pretzels and sipping on—you guessed it—ginger ale.

The study was funded by the National Cancer Institute.


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