Pros and Cons of 10 Fibromyalgia Treatments

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Pregabalin (Lyrica)

Pros: FDA approved for fibromyalgia, pregabalin (Lyrica) is a seizure drug that reduces the release of pain signals from nerves, and may have spillover benefits on sleep quality.

Cons: It's not effective in everyone, and even if it does work, it often reduces pain by only 30% to 40% , says Jianguo Cheng, MD, professor and director of the Cleveland Clinic Pain Medicine Fellowship Program, in Ohio. "You have to treat at least three people with fibromyalgia with pregabalin to make one person 30% better," he says. Side effects may include dizziness, sleepiness, headache, dry mouth, difficulty concentrating, nausea, and vomiting.

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