10 Most Depressing States in the U.S.


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The poorest state in the U.S., Mississippi ranks at or near the bottom on many health measures, from obesity to heart disease. Mental health is no exception. The state has the highest rate of depression in the nation (14.8%), according to the Centers for Disease Control and Prevention (CDC), and it has the third-highest rate of frequent mental distress (13.5%).

Indeed, the state’s many health problems may feed one another. "Depression can both precipitate and exacerbate the symptoms of a chronic disease," Lela McKnight-Eily, PhD, a clinical psychologist and epidemiologist at the CDC, told Health.com in 2010.

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