Warning: Do Not Mix These Supplements

Even the most common supplements can have surprising interactions with drugs and other supplements.
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Drug interactions: Since melatonin may make you drowsy, taking it with sedative drugs may cause too much sleepiness. Melatonin may slow blood clotting, so taking it with anticoagulant medications such as heparin or warfarin (Coumadin) may increase the chances of bruising and bleeding. Avoid using melatonin if you're taking medication to control blood pressure, as it may raise blood pressure.

Supplement interactions: Taking melatonin with other supplements that have sedative properties (including St. John's wort and valerian) may increase the effects and side effects of melatonin.

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