9 Medications That Can Cause Heartburn

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Tricyclic antidepressants

Some of the older tricyclic antidepressants (such as imipramine or amitriptyline) may contribute to heartburn by slowing the speed at which the stomach empties, Dr. Kaul explains.

“If the stomach isn’t emptying as it’s supposed to, then acid and food products will sit there for a long time and will be more likely to reflux back,” he says.

Generally speaking, newer psychiatric drugs work in a more targeted way and have fewer gastrointestinal side effects.

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