1. Arthritis meds
"Peyronie's disease ends up being arthritis of the penis," says Irwin Goldstein, MD, director of San Diego Sexual Medicine and the editor in chief of the Journal of Sexual Medicine. "So there are a number of therapies for arthritis that can be used for Peyronie's, like anti-inflammatories." Anti-inflammatory treatments include Potaba, which the Food and Drug Administration has labeled "possibly effective" for treating Peyronie's disease, as well as colchicine. However, large doses of Potaba are needed for this treatment, and it may cause stomach upset.
Your doctor may choose to try an injection to help reduce the swelling and pain associated with Peyronie's disease. "Injecting drugs such as collagenase, verapamila calcium channel blockerand interferon-alpha-2b is an option," says Dr. Goldstein, "though only interferon has been shown to be effective."
One of the best ways to stop pain that is resistant to more conservative treatments (such as ibuprofen), says Dr. Goldstein, is through steroids and steroid nerve blocks. He sometimes recommends injecting a steroid such as Kenalog, along with an anesthetic such as lidocaine, into the penis for quick relief of debilitating pain.