"Peyronie's disease ends up being arthritis of the penis," says Irwin Goldstein, MD, director of San Diego Sexual Medicine and the editor in chief of the Journal of Sexual Medicine. "So there are a number of therapies for arthritis that can be used for Peyronie's, like anti-inflammatories." Anti-inflammatory treatments include Potaba, which the Food and Drug Administration has labeled "possibly effective" for treating Peyronie's disease, as well as colchicine. However, large doses of Potaba are needed for this treatment, and it may cause stomach upset.
Your doctor may choose to try an injection to help reduce the swelling and pain associated with Peyronie's disease. "Injecting drugs such as collagenase, verapamila calcium channel blockerand interferon-alpha-2b is an option," says Dr. Goldstein, "though only interferon has been shown to be effective."
One of the best ways to stop pain that is resistant to more conservative treatments (such as ibuprofen), says Dr. Goldstein, is through steroids and steroid nerve blocks. He sometimes recommends injecting a steroid such as Kenalog, along with an anesthetic such as lidocaine, into the penis for quick relief of debilitating pain.
Not all doctors agree on treatment with medications. Ira Sharlip, MD, spokesman for the American Urological Association and clinical professor of urology at University of California at San Francisco, believes there aren't any effective treatments other than corrective surgery.
Nesbit procedure (or Nesbit plication): Tissues in the area of the penis opposite the affected ones are removed or pinched to correct the bend. The procedure can shorten the length of the erect penis, however, so doctors generally reserve this surgery for men with adequate penis length and cases that don't involve an extreme curvature.