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Journey: Prescription Sleep Drugs

Understanding Hypnotics: Benzodiazepine and Non-Benzodiazepine Sleep Medications


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Some people may need medicine for a while to help them fall asleep. Doctors often prescribe medicine for a short time if other treatment isn't working. But medicine doesn't work as well over time as lifestyle and behavior changes do.1 Sleep medicine can also become habit-forming. Medicine works best as a short-term treatment combined with lifestyle and behavior changes.

Benzodiazepines provide short-term relief from insomnia. These medicines help you fall asleep and stay asleep. Examples are quazepam (Doral), diazepam (such as Valium), and lorazepam (Ativan). Side effects of benzodiazepines can include:2

  • Dependence and withdrawal symptoms. Sleep problems may get worse when you stop taking the medicine.
  • Daytime drowsiness and dizziness.
  • Physical problems, such as falling, especially in older people.

Benzodiazepines make it hard to recall memories. They also seem to affect how much of the hormone melatonin your body makes at night. Melatonin helps you sleep and wake up on a regular schedule.3

Caution

  • In rare cases, people taking these medicines have done activities, such as driving and eating, while still asleep.
  • Using some hypnotics may actually make sleep apnea and other breathing disorders worse.2
  • These medicines can cause a serious allergic reaction (anaphylaxis).

References

Citations

  1. Smith MT, et al. (2002). Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. American Journal of Psychiatry, 159(1): 5–11.

  2. Estivill E, et al. (2003). Consensus on drug treatment, definition, and diagnosis for insomnia. Clinical Drug Investigations, 23(6): 351–385.

  3. Garfinkel D, et al. (1999). Facilitation of benzodiazepine discontinuation by melatonin. Archives of Internal Medicine, 159(20): 2456–2460.

Last Updated: April 20, 2008

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Last Updated: January 22, 2008
Author:
Maria G. Essig, MS, ELS
Medical Review:
Anne C. Poinier, MD - Internal Medicine

Catherine D. Serio, PhD - Behavioral Health

Jan Ulfberg, MD, PhD - Sleep Disorders


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