Overuse of painkillers for headaches can, ironically, lead to rebound headaches. Culprits include over-the-counter medications like aspirin, acetaminophen (Tylenol), or ibuprofen (Motrin, Advil), as well as prescription drugs.
"Most of the patients we see in a headache center with daily headache have medication-overuse, or rebound, headaches," says Stewart Tepper, MD, director of research at the Center for Headache and Pain at the Cleveland Clinic Neurological Institute.
"They are on a merry-go-round and they can't get off," says Dr. Tepper. "They keep taking more medicine, they keep having more headaches, and so the patient becomes more and more desperate. That's when they end up coming to headache specialists to kind of reset the whole system."
One theory is that too much medication can cause the brain to shift into an excited state, triggering more headaches. Another is that the headaches are a symptom of withdrawal as the level of medicine drops in the bloodstream.
Migraine headaches
Migraine headaches come from a neurological disorder that can run in families and are defined by certain criteria.
- At least five previous episodes of headaches
- Lasting between four hours and 72 hours
- Having at least two out of four of these features: one-sided pain, throbbing pain, moderate-to-severe pain, and pain that interferes with, is worsened by, or prohibits routine activity
- Having at least one associated feature: nausea and/or vomiting, or, if those are not present, then sensitivity to light and sound
Take the Migraine Quiz: Find out what really triggers that debilitating pain in your head.




